Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species
نویسندگان
چکیده
منابع مشابه
Nucleotide substitutions in the Candida albicans ERG11 gene of azole-susceptible and azole-resistant clinical isolates.
One of the mechanisms of Candida albicans resistance to azole drugs used in antifungal therapy relies on increased expression and presence of point mutations in the ERG11 gene that encodes sterol 14α demethylase (14DM), an enzyme which is the primary target for the azole class of antifungals. The aim of the study was to analyze nucleotide substitutions in the Candida albicans ERG11 gene of azol...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2016
ISSN: 1678-8060,0074-0276
DOI: 10.1590/0074-02760150400